Hs2st1^tm1.1Je
Targeted Allele Detail

Summary

• Symbol: Hs2st1^tm1.1Je
• Name: heparan sulfate 2-O-sulfotransferase 1; targeted mutation 1.1, Jeffrey D Esko
• MGI ID: MGI:4439161
• Synonyms: Hs2st^f
• Gene: Hs2st1 Location: Chr3:144135467-144275942 bp, - strand Genetic Position: Chr3, 68.89 cM
• Alliance: Hs2st1^tm1.1Je page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158299
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted into exon 1, 167 nucleotides upstream of the start codon, and downstream of this exon. This exon encodes a short 5' UTR and 40 amino acids of the 356 including the signal peptide. Cre mediated recombination removed the selction cassette leaving exon 1 floxed. (J:158299)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Hs2st1 Mutation: 33 strains or lines available

References

• Original: J:158299 Stanford KI, et al., Heparan sulfate 2-O-sulfotransferase is required for triglyceride-rich lipoprotein clearance. J Biol Chem. 2010 Jan 1;285(1):286-94
• All: 9 reference(s)