Hs2st1^tm1.2Je
Targeted Allele Detail

Summary

• Symbol: Hs2st1^tm1.2Je
• Name: heparan sulfate 2-O-sulfotransferase 1; targeted mutation 1.2, Jeffrey D Esko
• MGI ID: MGI:4439258
• Synonyms: zp3Hs2st-
• Gene: Hs2st1 Location: Chr3:144135467-144275942 bp, - strand Genetic Position: Chr3, 68.89 cM
• Alliance: Hs2st1^tm1.2Je page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158299
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, which contains the start codon, was removed by cre mediated recombination. Analysis of enzymatic activity and disaccharide analysis confirms grossly defective 2-O-sulfation. (J:158299)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hs2st1 Mutation: 33 strains or lines available

References

• Original: J:158299 Stanford KI, et al., Heparan sulfate 2-O-sulfotransferase is required for triglyceride-rich lipoprotein clearance. J Biol Chem. 2010 Jan 1;285(1):286-94
• All: 1 reference(s)