Prkab1^tm1Eihl
Targeted Allele Detail

Summary

• Symbol: Prkab1^tm1Eihl
• Name: protein kinase, AMP-activated, beta 1 non-catalytic subunit; targeted mutation 1, Bruce E Kemp
• MGI ID: MGI:4439277
• Synonyms: beta1^-
• Gene: Prkab1 Location: Chr5:116151654-116162449 bp, - strand Genetic Position: Chr5, 56.1 cM, cytoband F
• Alliance: Prkab1^tm1Eihl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158295
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 2 through 4 were deleted resulting in a premature termination in exon 6. The absence of protein expression was confirmed by western blot analysis on liver extracts. (J:158295)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkab1 Mutation: 24 strains or lines available

References

• Original: J:158295 Dzamko N, et al., AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance. J Biol Chem. 2010 Jan 1;285(1):115-22
• All: 20 reference(s)