Rb1^tm2.1Dwg
Targeted Allele Detail

Summary

• Symbol: Rb1^tm2.1Dwg
• Name: RB transcriptional corepressor 1; targeted mutation 2.1, David W Goodrich
• MGI ID: MGI:4439301
• Synonyms: Rb1^T
• Gene: Rb1 Location: Chr14:73430298-73563446 bp, - strand Genetic Position: Chr14, 38.73 cM, cytoband D3
• Alliance: Rb1^tm2.1Dwg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158408
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

Allele Type: Targeted (No functional change, Reporter) Mutation: Insertion Mutation details: A loxP site flanked neomycin resistance gene cassette and a dual affinity tag (His and Flag separated with a TEV site) were inserted upstream of exon 27. Cre-mediated recombination removed the neo cassette. (J:158408)

Generation of the Rb1^tm2.1Dwg allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rb1 Mutation: 111 strains or lines available

References

• Original: J:158408 Xiao H, et al., Construction of a dual affinity tagged allele of the Rb1 tumor suppressor gene in the mouse. Genesis. 2010 Feb;48(2):121-6
• All: 1 reference(s)