Pgr^tm4.2Lyd
Targeted Allele Detail

Summary

• Symbol: Pgr^tm4.2Lyd
• Name: progesterone receptor; targeted mutation 4.2, John P Lydon
• MGI ID: MGI:4439306
• Synonyms: PR^d
• Gene: Pgr Location: Chr9:8899834-8968612 bp, + strand Genetic Position: Chr9, 2.46 cM
• Alliance: Pgr^tm4.2Lyd page

Uterine defects in Pgr^tm4.2Lyd/Pgr^tm4.2Lyd and Pgr^tm1Bwo/Pgr^tm1Bwo mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158406
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted into intron 1 and an FRT site flanked neomycin reistance gene cassette with a 5' loxP site was inserted into intron 2. Flp-mediated recombination removed the neo cassette. Exon 2 was removed by cre-mediated recombination. The absence of protein expression was confirmed by immunohistochemistry on uterine sections. (J:158406)

Generation of the Pgr^tm4.1Lyd and Pgr^tm4.2Lyd alleles

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pgr^tm4.2Lyd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pgr Mutation: 75 strains or lines available

References

• Original: J:158406 Fernandez-Valdivia R, et al., A mouse model to dissect progesterone signaling in the female reproductive tract and mammary gland. Genesis. 2010 Feb;48(2):106-13
• All: 3 reference(s)