Agap2^tm1Kye
Targeted Allele Detail

Summary

• Symbol: Agap2^tm1Kye
• Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2; targeted mutation 1, Keqiang Ye
• MGI ID: MGI:4439322
• Synonyms: PIKE flox
• Gene: Agap2 Location: Chr10:126911154-126929039 bp, + strand Genetic Position: Chr10, 74.5 cM
• Alliance: Agap2^tm1Kye page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158376
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 6. (J:158376)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agap2 Mutation: 50 strains or lines available

References

• Original: J:158376 Chan CB, et al., PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development. EMBO J. 2010 Mar 3;29(5):956-68
• All: 4 reference(s)