Huwe1^tm1Alas
Targeted Allele Detail

Summary

• Symbol: Huwe1^tm1Alas
• Name: HECT, UBA and WWE domain containing 1; targeted mutation 1, Anna Lasorella
• MGI ID: MGI:4439480
• Synonyms: Huwe1^flox
• Gene: Huwe1 Location: ChrX:150583803-150718413 bp, + strand Genetic Position: ChrX, 68.46 cM
• Alliance: Huwe1^tm1Alas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152966
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The allele was created by inserting an FRT-flanked pGKNeoR cassette into intron 82 and loxP sites into intron 79 and 82. Exons 80-82 encode most of the HECT domain of Huwe1. (J:145660)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Huwe1 Mutation: 63 strains or lines available

References

• Original: J:145660 Zhao X, et al., The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein. Nat Cell Biol. 2008 Jun;10(6):643-53
• All: 12 reference(s)