Sh3pxd2b^{Gt(GST_1527_E5)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Sh3pxd2b^{Gt(GST_1527_E5)Lex}
• Name: SH3 and PX domains 2B; gene trap GST_1527_E5, Lexicon Genetics
• MGI ID: MGI:4439499
• Synonyms: Tks4^-
• Gene: Sh3pxd2b Location: Chr11:32297820-32378173 bp, + strand Genetic Position: Chr11, 18.89 cM
• Alliance: Sh3pxd2b^{Gt(GST_1527_E5)Lex} page

Mutation origin

• Mutant Cell Line: GST_1527_E5
• Germline Transmission: Earliest citation of germline transmission: J:158635
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: VICTR48 Vector Type: gene trap
• Mutation details: The gene trap vector inserted between exon 3 and 4. The absence of protein expression was confirmed by western blot analysis on E12.5 fibroblast extracts. (J:158635)

Expression

In Structures Affected by this Mutation:

19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh3pxd2b Mutation: 38 strains or lines available

References

• Original: J:158635 Iqbal Z, et al., Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter Haar Syndrome. Am J Hum Genet. 2010 Feb 12;86(2):254-61
• All: 2 reference(s)