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Lmnb2tm1Ccof
Targeted Allele Detail
Summary
Symbol: Lmnb2tm1Ccof
Name: lamin B2; targeted mutation 1, Catherine Coffinier
MGI ID: MGI:4440427
Gene: Lmnb2  Location: Chr10:80737197-80754079 bp, - strand  Genetic Position: Chr10, 39.72 cM, cytoband C
Alliance: Lmnb2tm1Ccof page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158610
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with an AUG-lacZ and floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on embryonic fibroblast extracts. (J:158610)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmnb2 Mutation:  27 strains or lines available
References
Original:  J:158610 Coffinier C, et al., Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5076-81
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory