Lmnb2^tm1Ccof
Targeted Allele Detail

Summary

• Symbol: Lmnb2^tm1Ccof
• Name: lamin B2; targeted mutation 1, Catherine Coffinier
• MGI ID: MGI:4440427
• Gene: Lmnb2 Location: Chr10:80737197-80754079 bp, - strand Genetic Position: Chr10, 39.72 cM, cytoband C
• Alliance: Lmnb2^tm1Ccof page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158610
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with an AUG-lacZ and floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on embryonic fibroblast extracts. (J:158610)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmnb2 Mutation: 27 strains or lines available

References

• Original: J:158610 Coffinier C, et al., Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5076-81
• All: 3 reference(s)