Doc2b^tm1Aljg
Targeted Allele Detail

Summary

• Symbol: Doc2b^tm1Aljg
• Name: double C2, beta; targeted mutation 1, Alexander J Groffen
• MGI ID: MGI:4440451
• Gene: Doc2b Location: Chr11:75659792-75686875 bp, - strand Genetic Position: Chr11, 45.92 cM
• Alliance: Doc2b^tm1Aljg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158605
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The promoter and exon 1 was replaced with a floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:158605)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Doc2b Mutation: 20 strains or lines available

References

• Original: J:158605 Groffen AJ, et al., Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release. Science. 2010 Mar 26;327(5973):1614-8
• All: 12 reference(s)