Dnajc6^tm1Legr
Targeted Allele Detail

Summary

• Symbol: Dnajc6^tm1Legr
• Name: DnaJ heat shock protein family (Hsp40) member C6; targeted mutation 1, Lois Greene
• MGI ID: MGI:4440489
• Synonyms: Dnajc6^tm1Pdc
• Gene: Dnajc6 Location: Chr4:101353828-101499996 bp, + strand Genetic Position: Chr4, 46.89 cM
• Alliance: Dnajc6^tm1Legr page

Accumulation of clathrin-coated vesicles and clathrin cages at Dnajc6^tm1Legr/Dnajc6^tm1Legr synapses from deep cerebellar nuclei

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158574
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Part of exon 3 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:158574)

Generation of the Dnajc6^tm1Legr allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dnajc6 Mutation: 62 strains or lines available

Notes

ES cell line = GSI

References

• Original: J:158574 Yim YI, et al., Endocytosis and clathrin-uncoating defects at synapses of auxilin knockout mice. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4412-7
• All: 4 reference(s)