Tg(Thy1-Sncg)HvP36Putt
Transgene Detail

Summary

• Symbol: Tg(Thy1-Sncg)HvP36Putt
• Name: transgene insertion HvP36, Herman van der Putten
• MGI ID: MGI:4440514
• Synonyms: Thy1mgammaSN
• Transgene: Tg(Thy1-Sncg)HvP36Putt Location: unknown
• Alliance: Tg(Thy1-Sncg)HvP36Putt page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-Sncg)HvP36Putt expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Sncg (MGI:1298397)

• Mutation details: The Thy1mgammaSN transgene was designed to contain the mouse gamma-synuclein gene driven by the neuron-specific mouse thymus cell antigen 1 (Thy-1) promoter. Founder line HvP36 was established. (J:147580)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1	Tg(Thy1-Sncg)HvP36Putt/Tg(Thy1-Sncg)HvP36Putt	C57BL/6-Tg(Thy1-Sncg)HvP36Putt
tg2	Tg(Thy1-Sncg)HvP36Putt/0	C57BL/6-Tg(Thy1-Sncg)HvP36Putt
tg3  Disease Model	Tg(Thy1-Sncg)HvP36Putt/?	C57BL/6-Tg(Thy1-Sncg)HvP36Putt

Phenotypes:

Affected Systems	tg1	tg2	tg3
show or hide all annotated terms
behavior/neurological	√	√
limb grasping	√
abnormal motor coordination/balance	√	√
impaired righting response	√
impaired balance	√
impaired coordination	√	√
hunched posture	√
abnormal gait	√
short stride length	√	√
paralysis	√
paresis	√
hematopoietic system			√
microgliosis			√
homeostasis/metabolism	√	√
amyloidosis	√	√
immune system			√
microgliosis			√
mortality/aging	√
premature death	√
nervous system	√	√	√
nervous system phenotype			N
abnormal nervous system morphology	√
gliosis			√
microgliosis			√
astrocytosis	√	√	√
decreased motor neuron number	√	√	√
abnormal myelin sheath morphology			√
neuron degeneration			√
abnormal trigeminal nerve morphology			√
abnormal dorsal spinal root morphology			√
abnormal sciatic nerve morphology			√
abnormal ventral spinal root morphology			√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	tg3
amyotrophic lateral sclerosis type 1 IDs amyotrophic lateral sclerosis type 1       DOID:0060193 ICD10CM:G12.2 OMIM:105400 Close	√

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:147580 Ninkina N, et al., Gamma-synucleinopathy: neurodegeneration associated with overexpression of the mouse protein. Hum Mol Genet. 2009 May 15;18(10):1779-94
• All: 3 reference(s)