Dapk1^tm1Akc
Targeted Allele Detail

Summary

• Symbol: Dapk1^tm1Akc
• Name: death associated protein kinase 1; targeted mutation 1, Adi Kimchi
• MGI ID: MGI:4440532
• Synonyms: DAPk-
• Gene: Dapk1 Location: Chr13:60749761-60911005 bp, + strand Genetic Position: Chr13, 32.53 cM
• Alliance: Dapk1^tm1Akc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158109
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted into the first exon of the gene. Gene deletion was confirmed by PCR, western blot and northern blot analysis. (J:158109)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dapk1 Mutation: 126 strains or lines available

References

• Original: J:158109 Gozuacik D, et al., DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death. Cell Death Differ. 2008 Dec;15(12):1875-86
• All: 10 reference(s)