Del(4C4-C5)1Lap
Targeted Allele Detail

Summary

• Symbol: Del(4C4-C5)1Lap
• Name: deletion, Chr 4, Len A Pennacchio 1
• MGI ID: MGI:4440552
• Synonyms: ANRIL^-, chr4^delta70kb, Del1Lap
• Gene: Del(4C4-C5)1Lap Location: unknown Genetic Position: Chr4, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158126
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(4C4-C5)1Lap involves 1 genes/genome features (Gm12610) View all
• Mutation details: Cre mediated recombination removed a floxed 70 kb region corresponding to the human 9p21 non-coding coronary artery disease risk interval. The 5' targeting vector contained a 5' homologous region and loxP site upstream of a neo cassette while the 3' targeting vector contained a copy of the 3' homologous region and hygro cassette upstream of a loxP site. Reduced expression of Cdkn2a and Cdkn2b was confirmed by qRT-PCR on heart and other tissue extracts. (J:158126)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(4C4-C5)1Lap Mutation: 0 strains or lines available

References

• Original: J:158126 Visel A, et al., Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature. 2010 Mar 18;464(7287):409-12
• All: 8 reference(s)