Tg(PDGFB-Adra2b)13Hag
Transgene Detail

Summary

• Symbol: Tg(PDGFB-Adra2b)13Hag
• Name: transgene insertion 13, Haralambos Gavras
• MGI ID: MGI:4440595
• Synonyms: TG13
• Transgene: Tg(PDGFB-Adra2b)13Hag Location: unknown
• Alliance: Tg(PDGFB-Adra2b)13Hag page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(PDGFB-Adra2b)13Hag expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Adra2b (MGI:87935)

• Mutation details: The transgenic construct contained the mouse alpha 2b adrenergic receptor followed by a human growth hormone polyA signal under the control of a human platelet-derived growth factor-beta chain promoter (PDGFB). Three founder lines (10, 13, and 16) were established. (J:158792)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1	Tg(PDGFB-Adra2b)13Hag/0	involves: FVB

Phenotypes:

Affected Systems	tg1
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cardiovascular system	√
increased systemic arterial systolic blood pressure	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:158792 Kintsurashvili E, et al., Hypertension in transgenic mice with brain-selective overexpression of the alpha(2B)-adrenoceptor. Am J Hypertens. 2009 Jan;22(1):41-5
• All: 2 reference(s)