Ccn3^tm1.1Ecan
Targeted Allele Detail

Summary

• Symbol: Ccn3^tm1.1Ecan
• Name: cellular communication network factor 3; targeted mutation 1.1, Ernesto Canalis
• MGI ID: MGI:4440613
• Gene: Ccn3 Location: Chr15:54609306-54617158 bp, + strand Genetic Position: Chr15, 21.49 cM
• Alliance: Ccn3^tm1.1Ecan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158478
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ or C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region was replaced with a LacZ and floxed neo cassette. The absence of transcript was confirmed by RT-PCR on calvarial extracts. (J:158478)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccn3 Mutation: 22 strains or lines available

References

• Original: J:158478 Canalis E, et al., Nephroblastoma overexpressed (Nov) inactivation sensitizes osteoblasts to bone morphogenetic protein-2, but nov is dispensable for skeletal homeostasis. Endocrinology. 2010 Jan;151(1):221-33
• All: 1 reference(s)