Sec24b^Y613X
Chemically induced Allele Detail

Summary

• Symbol: Sec24b^Y613X
• Name: SEC24 homolog B, COPII coat complex component; Tyr613Stop
• MGI ID: MGI:4440619
• Synonyms: Sec24b⁸¹¹, Sec24b^Y613
• Gene: Sec24b Location: Chr3:129776408-129855202 bp, - strand Genetic Position: Chr3, 59.87 cM
• Alliance: Sec24b^Y613X page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to A transversion in exon 9 (1834T>A in ENSMUST00000098616). This mutation results in an amino acid substitution of a stop codon at position 613 in a Sec23/24-binding domain instead of tyrosine (Y613X). (J:158452)

Expression

In Mice Carrying this Mutation:

5 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sec24b Mutation: 68 strains or lines available

References

• Original: J:158452 Merte J, et al., Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure. Nat Cell Biol. 2010 Jan;12(1):41-6; sup pp 1-8
• All: 2 reference(s)