Sec24b^krb
Chemically induced Allele Detail

Summary

• Symbol: Sec24b^krb
• Name: SEC24 homolog B, COPII coat complex component; krabbel
• MGI ID: MGI:4440621
• Synonyms: 59458-3, Sec24b^S135X
• Gene: Sec24b Location: Chr3:129776408-129855202 bp, - strand Genetic Position: Chr3, 59.87 cM
• Alliance: Sec24b^krb page

Lung development is affected in Sec24b^krb/Sec24b^krb embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a C to A transition at nucleotide 304 of exon 2 (ENMUST00000001079) that result in the amino acid substitution of a stop codon for serine at position 135 (S135X). A 72% reduction in transcript expression was confirmed by qRT-PCR. (J:158452, J:158680)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sec24b Mutation: 68 strains or lines available

References

• Original: J:158680 Wansleeben C, et al., Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b. Development. 2010 Apr;137(7):1067-73
• All: 4 reference(s)