Scrib^m51206BHubr
Spontaneous Allele Detail

Summary

• Symbol: Scrib^m51206BHubr
• Name: scribbled planar cell polarity; mutation 51206B, Hubrecht Institute
• MGI ID: MGI:4440642
• Synonyms: 5120-6B, Scrib⁵¹²⁰⁶, Scrib^R1508X
• Gene: Scrib Location: Chr15:75919011-75941633 bp, - strand Genetic Position: Chr15, 35.29 cM
• Alliance: Scrib^m51206BHubr page

Lung development is affected in Scrib^m51206BHubr/Scrib^m51206BHubr embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a C-to-T transition at coding nucleotide 4522 (ENSMUST00000002603) in exon 33. This mutation results in a nonsense mutation of arginine 1508 truncating the protein by 158 amino acids (p.R1508*). A 65% reduction in transcript expression was confirmed by qRT-PCR. (J:158680)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scrib Mutation: 54 strains or lines available

References

• Original: J:158680 Wansleeben C, et al., Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b. Development. 2010 Apr;137(7):1067-73
• All: 2 reference(s)