Bhlhe22^tm1Meg
Targeted Allele Detail

Summary

• Symbol: Bhlhe22^tm1Meg
• Name: basic helix-loop-helix family, member e22; targeted mutation 1, Michael E Greenberg
• MGI ID: MGI:4440742
• Synonyms: Bhlhb5^-
• Gene: Bhlhe22 Location: Chr3:18108489-18111678 bp, + strand Genetic Position: Chr3, 4.98 cM, cytoband A2
• Alliance: Bhlhe22^tm1Meg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158273
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The single exon of Bhlhe22 was replaced with a PGK-neo cassette by homologous recombination in ES cells, resulting in a null allele. (J:158273)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bhlhe22 Mutation: 12 strains or lines available

References

• Original: J:158273 Ross SE, et al., Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron. 2010 Mar 25;65(6):886-98
• All: 4 reference(s)