Bhlhe22^{tm3.1(cre)Meg}
Targeted Allele Detail

Summary

• Symbol: Bhlhe22^{tm3.1(cre)Meg}
• Name: basic helix-loop-helix family, member e22; targeted mutation 3.1, Michael E Greenberg
• MGI ID: MGI:4440745
• Synonyms: B5-cre, Bhlhb5-cre, Bhlhe22-Cre
• Gene: Bhlhe22 Location: Chr3:18108489-18111678 bp, + strand Genetic Position: Chr3, 4.98 cM, cytoband A2
• Alliance: Bhlhe22^{tm3.1(cre)Meg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158273
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Bhlhe22^{tm3.1(cre)Meg} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Bhlhe22 (MGI:1930001)

• Mutation details: The coding region of the Bhlhe22 gene was replaced by the coding sequence of cre recombinase and a loxP flanked neo selection cassette via homologous recombination in ES cells. The neo was removed in the ES cells by cre-mediated excision. (J:158273)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Bhlhe22 (mouse) Summary of all recombinase alleles driven by Bhlhe22. Alliance mouse Bhlhe22 gene page

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bhlhe22 Mutation: 12 strains or lines available

References

• Original: J:158273 Ross SE, et al., Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron. 2010 Mar 25;65(6):886-98
• All: 13 reference(s)