Stk11^tm1.1Sjm
Targeted Allele Detail

Summary

• Symbol: Stk11^tm1.1Sjm
• Name: serine/threonine kinase 11; targeted mutation 1.1, Sean J Morrison
• MGI ID: MGI:4440829
• Synonyms: Lkb1^fl, Stk11^fl
• Gene: Stk11 Location: Chr10:79951637-79966516 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Stk11^tm1.1Sjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165090
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 5'loxP site was inserted upstream of exon 3 and an additional loxP site was inserted downstream of exon 6. Flp mediated recombination removed the neo cassette. (J:165090)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Stk11^tm1.1Sjm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stk11 Mutation: 35 strains or lines available

References

• Original: J:165090 Nakada D, et al., Lkb1 regulates cell cycle and energy metabolism in hematopoietic stem cells. Nature. 2010;468(7324):653-658
• All: 53 reference(s)