Uhrf1^tm1Hko
Targeted Allele Detail

Summary

• Symbol: Uhrf1^tm1Hko
• Name: ubiquitin-like, containing PHD and RING finger domains, 1; targeted mutation 1, Haruhiko Koseki
• MGI ID: MGI:4440836
• Synonyms: Np95^-
• Gene: Uhrf1 Location: Chr17:56610405-56630486 bp, + strand Genetic Position: Chr17, 29.26 cM, cytoband D-E1
• Alliance: Uhrf1^tm1Hko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129097
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin selection cassette in reverse orientation replaced exons 2 through 7. (J:129097)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Uhrf1 Mutation: 52 strains or lines available

References

• Original: J:129097 Sharif J, et al., The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA. Nature. 2007 Dec 6;450(7171):908-12
• All: 2 reference(s)