Ces1d^tm1Reli
Targeted Allele Detail

Summary

• Symbol: Ces1d^tm1Reli
• Name: carboxylesterase 1D; targeted mutation 1, Richard Lehner
• MGI ID: MGI:4440967
• Synonyms: Ces1d^tm1Rile, Tgh^-
• Gene: Ces1d Location: Chr8:93892700-93924432 bp, - strand Genetic Position: Chr8, 45.05 cM, cytoband C5
• Alliance: Ces1d^tm1Reli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158743
• Parent Cell Line: iTL1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5, which encodes the catalytic serine at position 221, was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on liver extracts. (J:158743)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ces1d Mutation: 41 strains or lines available

References

• Original: J:158743 Wei E, et al., Loss of TGH/Ces3 in mice decreases blood lipids, improves glucose tolerance, and increases energy expenditure. Cell Metab. 2010 Mar 3;11(3):183-93
• All: 7 reference(s)