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Pag1tm1Tara
Targeted Allele Detail
Summary
Symbol: Pag1tm1Tara
Name: phosphoprotein associated with glycosphingolipid microdomains 1; targeted mutation 1, Alexander Tarakhovsky
MGI ID: MGI:4441056
Synonyms: CbploxP
Gene: Pag1  Location: Chr3:9752539-9898739 bp, - strand  Genetic Position: Chr3, 2.47 cM
Alliance: Pag1tm1Tara page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159011
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neomycin resistance cassette was inserted in intron 1 and a third loxP site was placed in intron 2 just downstream of exon 2. The selection cassette was then removed from properly targeted ES cells by transient cre expression. (J:159011)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pag1 Mutation:  21 strains or lines available
References
Original:  J:159011 Dobenecker MW, et al., The ubiquitously expressed Csk adaptor protein Cbp is dispensable for embryogenesis and T-cell development and function. Mol Cell Biol. 2005 Dec;25(23):10533-42
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory