Rev3l^tm2.1Rwd
Targeted Allele Detail

Summary

• Symbol: Rev3l^tm2.1Rwd
• Name: REV3 like, DNA directed polymerase zeta catalytic subunit; targeted mutation 2.1, Richard D Wood
• MGI ID: MGI:4441207
• Synonyms: Rev3L^loxP
• Gene: Rev3l Location: Chr10:39608114-39751207 bp, + strand Genetic Position: Chr10, 21.04 cM
• Alliance: Rev3l^tm2.1Rwd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158922
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the exon encoding part of the DNA polymerase motif 1 and downstream of the exon encoding all of the DNA polymerase motif 5. A floxed neo cassette used for cell selection was removed by cre-mediated recombination leaving the floxed region intact. (J:158922)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rev3l Mutation: 120 strains or lines available

References

• Original: J:158922 Wittschieben JP, et al., Loss of DNA polymerase zeta enhances spontaneous tumorigenesis. Cancer Res. 2010 Apr 1;70(7):2770-8
• All: 4 reference(s)