Sp2^tm1Sus
Targeted Allele Detail

Summary

• Symbol: Sp2^tm1Sus
• Name: Sp2 transcription factor; targeted mutation 1, Guntram Suske
• MGI ID: MGI:4441277
• Synonyms: Sp2lzn
• Gene: Sp2 Location: Chr11:96844167-96873785 bp, - strand Genetic Position: Chr11, 60.17 cM, cytoband D
• Alliance: Sp2^tm1Sus page

Impaired development of Sp2^tm1Sus/Sp2^tm1Sus embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158671
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: Two loxP sites were inserted to flank exon 3 of the gene, followed by an SA-IRES-lacZ-neo-SVpA cassette and a third loxP site after the cassette in intron 3. Northern blot analyses revealed aberrant mRNA expression. Immunoblot analysis showed the absence of the full-length protein; a truncated N-terminal fragment was below the detection limit. (J:158671)

Generation of the Sp2^tm1Sus allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sp2 Mutation: 151 strains or lines available

References

• Original: J:158671 Baur F, et al., Specificity protein 2 (Sp2) is essential for mouse development and autonomous proliferation of mouse embryonic fibroblasts. PLoS One. 2010;5(3):e9587
• All: 1 reference(s)