Sirt2^tm1.1Fwa
Targeted Allele Detail

Summary

• Symbol: Sirt2^tm1.1Fwa
• Name: sirtuin 2; targeted mutation 1.1, Frederick W Alt
• MGI ID: MGI:4441346
• Gene: Sirt2 Location: Chr7:28466192-28488086 bp, + strand Genetic Position: Chr7, 16.92 cM, cytoband B1-2
• Alliance: Sirt2^tm1.1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177028
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 5-6 and part of exon 7 with a floxed PGK-neomycin (neo)-resistance cassette. Cre-mediated recombination removed the neo cassette. (J:177028, J:195041)

Expression

In Mice Carrying this Mutation:

3 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sirt2 Mutation: 27 strains or lines available

References

• Original: J:177028 Alt FW, Direct Data Submission. MGI Direct Data Submission. 2011
• All: 38 reference(s)