About   Help   FAQ
Ptprcltng
Chemically induced Allele Detail
Summary
Symbol: Ptprcltng
Name: protein tyrosine phosphatase receptor type C; lightning
MGI ID: MGI:4441612
Synonyms: PtprcL
Gene: Ptprc  Location: Chr1:137990599-138103446 bp, - strand  Genetic Position: Chr1, 60.73 cM
Alliance: Ptprcltng page
Mutation
origin
Strain of Origin:  C57BL/6
Project Collection: APF ENU Mutagenesis
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Nucleotide substitutions
 
Mutation detailsENU induced at T to C transition that results in the amino acid substitution of serine for phenylalanine at position 503 (F503S). Flow cytometry confirmed that protein half-life is reduced. (J:158876)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ptprc Mutation:  189 strains or lines available
References
Original:  J:158876 Zikherman J, et al., CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Immunity. 2010 Mar 26;32(3):342-54
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory