Chd6^tm1.2Fier
Targeted Allele Detail

Summary

• Symbol: Chd6^tm1.2Fier
• Name: chromodomain helicase DNA binding protein 6; targeted mutation 1.2, Steven Fiering
• MGI ID: MGI:4442238
• Gene: Chd6 Location: Chr2:160788898-160950995 bp, - strand Genetic Position: Chr2, 80.98 cM
• Alliance: Chd6^tm1.2Fier page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158513
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A floxed and FRT flanked neomycin cassette was inserted 5' to exon 12 and third loxP site inserted 3' to exon 12. The selection cassette and exon 12 were removed by cre mediated recombination. This deletion removes 81 amino acids of the SWI2/SNF2-like domain which encodes motif I, a key ATP-binding motif, and motif Ia, which has DNA-binding activity. The modified protein is produced at wild type levels. (J:158513)

Generation of a Chd6 Exon 12 -/- mouse line.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chd6 Mutation: 120 strains or lines available

References

• Original: J:158513 Lathrop MJ, et al., Deletion of the Chd6 exon 12 affects motor coordination. Mamm Genome. 2010 Apr;21(3-4):130-42
• All: 1 reference(s)