Pten^tm2.1Gle
Targeted Allele Detail

Summary

• Symbol: Pten^tm2.1Gle
• Name: phosphatase and tensin homolog; targeted mutation 2.1, Gustavo Leone
• MGI ID: MGI:4442331
• Synonyms: Pten^G129E
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm2.1Gle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158751
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: The codon GGA for Glycine 129 within exon 5, was mutated to GAA for Glutamate. In addition a floxed neo cassette was introduced within intron 4. The selection cassette was removed by cre mediated recombination. (J:158751)

Generation, targeting, and verification of point mutations of Pten alleles.

Disease models

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pten^tm2.1Gle

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 88 strains or lines available

References

• Original: J:158751 Wang H, et al., Allele-specific tumor spectrum in Pten knockin mice. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5142-7
• All: 3 reference(s)