Il25^tm1.1Cdon
Targeted Allele Detail

Summary

• Symbol: Il25^tm1.1Cdon
• Name: interleukin 25; targeted mutation 1.1, Chen Dong
• MGI ID: MGI:4442365
• Gene: Il25 Location: Chr14:55170152-55173294 bp, + strand Genetic Position: Chr14, 28.0 cM
• Alliance: Il25^tm1.1Cdon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158594
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were floxed and a neo cassette inserted after exon 3 but before the second loxP site by homologous recombination. The flanked exons and selection cassette were removed by cre mediated recombination. Absence of mRNA expression was confirmed by real-time PCR in lung tissue. (J:158594)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il25 Mutation: 15 strains or lines available

References

• Original: J:158594 Angkasekwinai P, et al., Regulation of IL-9 expression by IL-25 signaling. Nat Immunol. 2010 Mar;11(3):250-6
• All: 3 reference(s)