Gad1^tm1.1Bgc
Targeted Allele Detail

Summary

• Symbol: Gad1^tm1.1Bgc
• Name: glutamate decarboxylase 1; targeted mutation 1.1, Brian G Condie
• MGI ID: MGI:4442416
• Synonyms: Gad1^lacZ
• Gene: Gad1 Location: Chr2:70392109-70432358 bp, + strand Genetic Position: Chr2, 41.63 cM, cytoband D
• Alliance: Gad1^tm1.1Bgc page

Umbilical hernia in Gad1^tm1.1Bgc/Gad1^tm1.1Bgc mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158888
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing LacZ and a floxed MC1Neo was inserted into exon 2 producing an in frame fusion via homologous recombination. The neo was removed by Cre mediated recombination. (J:159165)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gad1 Mutation: 65 strains or lines available

References

• Original: J:159165 Westmoreland JJ, et al., Neuronal development of embryonic stem cells: a model of GABAergic neuron differentiation. Biochem Biophys Res Commun. 2001 Jun 15;284(3):674-80
• All: 2 reference(s)