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Pax3tm2Joe
Targeted Allele Detail
Summary
Symbol: Pax3tm2Joe
Name: paired box 3; targeted mutation 2, Jonathan A Epstein
MGI ID: MGI:4442462
Synonyms: Pax3NCE-neo
Gene: Pax3  Location: Chr1:78077904-78173771 bp, - strand  Genetic Position: Chr1, 39.79 cM
Alliance: Pax3tm2Joe page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159124
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, Modified regulatory region, No functional change)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 674 bp neural crest enhancer region within the upstream genomic region was replaced by a flowed PGK-neo cassette. Immunohistochemistry showed a drastic reduction or complete loss of protein expression in homozygous embryos at E12.5. Removal of the PGK-neo cassette with Cre-expressing mice allows for tissue-specific rescue. (J:159124)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pax3 Mutation:  50 strains or lines available
References
Original:  J:159124 Degenhardt KR, et al., Distinct enhancers at the Pax3 locus can function redundantly to regulate neural tube and neural crest expressions. Dev Biol. 2010 Mar 15;339(2):519-27
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory