Mboat4^tm1Vlcg
Targeted Allele Detail

Summary

• Symbol: Mboat4^tm1Vlcg
• Name: membrane bound O-acyltransferase domain containing 4; targeted mutation 1, Velocigene
• MGI ID: MGI:4442482
• Synonyms: Goat^-
• Gene: Mboat4 Location: Chr8:34582184-34592336 bp, + strand Genetic Position: Chr8, 20.9 cM
• Alliance: Mboat4^tm1Vlcg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159327
• Parent Cell Line: VGF1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: The entire coding region was replaced with a lacZ gene and neo cassette via homologous recombination. Quantitative RT-PCR confirmed the absence of transcript in the gastric mucosa from homozygous mice. (J:159327)

Generation of the Mboat4^tm1Vlcg allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mboat4 Mutation: 18 strains or lines available

References

• Original: J:159327 Zhao TJ, et al., Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7467-72
• All: 7 reference(s)