Fzd2^tm1.1Nat
Targeted Allele Detail

Summary

• Symbol: Fzd2^tm1.1Nat
• Name: frizzled class receptor 2; targeted mutation 1.1, Jeremy Nathans
• MGI ID: MGI:4442611
• Gene: Fzd2 Location: Chr11:102495257-102498884 bp, + strand Genetic Position: Chr11, 66.45 cM
• Alliance: Fzd2^tm1.1Nat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159434
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region for a nuclear-localized beta-galactosidase (nLacZ; using an SV40 nuclear localization signal) was targeted to the Fzd1 locus by homologous recombination. The nLacZ sequences replace the Fzd2 open reading frame. A LoxP-flanked neo selectable marker used for ES cell selection was removed by subsequent crossing to a mouse line expressing germline Cre recombinase. Sequences from the E coli tetracycline resistance gene (TetR) are included immediately 3' of the nLacZ sequences and are part of the 3' untranslated region of the nLacZ transcript. (J:159434)

Expression

In Mice Carrying this Mutation:	6 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fzd2 Mutation: 34 strains or lines available

References

• Original: J:159434 Nathans J, DDS for Fzd2^tm1.1Nat. MGI Direct Data Submission. 2010
• All: 5 reference(s)