Fzd8^tm1Nat
Targeted Allele Detail

Summary

• Symbol: Fzd8^tm1Nat
• Name: frizzled class receptor 8; targeted mutation 1, Jeremy Nathans
• MGI ID: MGI:4442631
• Synonyms: Fz8^lacZ
• Gene: Fzd8 Location: Chr18:9212856-9216201 bp, + strand Genetic Position: Chr18, 4.91 cM
• Alliance: Fzd8^tm1Nat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159436
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The open reading frame of the targeted gene was replaced by beta-galactosidase (LacZ) via homologous recombination in a 129-derived embryonic stem (ES) cell line. A PGK-neo selectable marker used for ES cell selection is present downstream of the LacZ sequences. (J:159436, J:170839)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fzd8 Mutation: 33 strains or lines available

References

• Original: J:159436 Nathans J, DDS for Fzd8^tm1Nat. MGI Direct Data Submission. 2010
• All: 4 reference(s)