Gpr149^tm1.1Zuk
Targeted Allele Detail

Summary

• Symbol: Gpr149^tm1.1Zuk
• Name: G protein-coupled receptor 149; targeted mutation 1.1, Martin M Matzuk
• MGI ID: MGI:4442841
• Gene: Gpr149 Location: Chr3:62436851-62512861 bp, - strand Genetic Position: Chr3, 29.97 cM
• Alliance: Gpr149^tm1.1Zuk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158302
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre mediated recombination removed exon 1 and the neo cassette. The absence of transcript expression was confirmed by RT-PCR on oocyte extracts. (J:158302)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Gpr149^tm1.1Zuk/Gpr149^tm1.1Zuk	involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
ht2	Gpr149^tm1.1Zuk/Gpr149^+	involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

Phenotypes:

Affected Systems	hm1	ht2
show or hide all annotated terms Sex:
endocrine/exocrine glands	√
increased secondary ovarian follicle number	√
increased tertiary ovarian follicle number	√
abnormal ovarian folliculogenesis	√
homeostasis/metabolism	N
homeostasis/metabolism phenotype	N
reproductive system	√	√
increased secondary ovarian follicle number	√
increased tertiary ovarian follicle number	√
abnormal ovarian folliculogenesis	√
increased ovulation rate	√
increased superovulation rate	√	√
abnormal estrous cycle	√
prolonged estrus	√
increased litter size	√
enhanced female fertility	√
abnormal fertilization	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr149 Mutation: 38 strains or lines available

References

• Original: J:158302 Edson MA, et al., Deletion of the novel oocyte-enriched gene, Gpr149, leads to increased fertility in mice. Endocrinology. 2010 Jan;151(1):358-68
• All: 1 reference(s)