Tap2^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tap2^m1Btlr
• Name: transporter 2, ATP-binding cassette, sub-family B (MDR/TAP); mutation 1, Bruce Beutler
• MGI ID: MGI:4442846
• Synonyms: ganymede
• Gene: Tap2 Location: Chr17:34423453-34435295 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: Tap2^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Insertion
• Mutation details: The mutation comprises the insertion of a single cytosine nucleotide (C) within a stretch of Cs located between nucleotides 1083 and 1087 of the mRNA sequence (Genbank accession NM_011530), in the fifth of the gene's 12 exons; the number of Cs in the sequence is increased from five to six. The resulting frameshifted transcript is predicted to encode aberrant amino acids from position 312 to 361 and to terminate prematurely at position 362. (J:159355)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tap2 Mutation: 28 strains or lines available

References

• Original: J:159355 Krebs P, et al., Ganymede is an allele of Tap2 resulting in CD8⁺ T-cell deficiency and lack of MHC class I expression on lymphocytes. MGI Direct Data Submission. 2010
• All: 1 reference(s)