Mir499^tm1.1Eno
Targeted Allele Detail

Summary

• Symbol: Mir499^tm1.1Eno
• Name: microRNA 499; targeted mutation 1, Eric N Olson
• MGI ID: MGI:4442864
• Gene: Mir499 Location: Chr2:155464800-155464878 bp, + strand Genetic Position: Chr2, 77.26 cM
• Alliance: Mir499^tm1.1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155756
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The micro-RNA sequence was replaced by a loxP and frt flanked neo cassette. Cre mediated recombination removes the neo cassette leaving a single loxP site in place of the micro-RNA. The absence of transcript expression was confirmed by northern blot analysis on heart extracts. (J:155756)

Expression

In Mice Carrying this Mutation:

33 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir499 Mutation: 1 strain or line available

References

• Original: J:155756 van Rooij E, et al., A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev Cell. 2009 Nov;17(5):662-73
• All: 2 reference(s)