Tyr^c-2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tyr^c-2Btlr
• Name: tyrosinase; albino 2 Bruce Beutler
• MGI ID: MGI:4442899
• Synonyms: pale rider, Tyr^m2Btlr
• Gene: Tyr Location: Chr7:87073979-87142637 bp, - strand Genetic Position: Chr7, 49.01 cM
• Alliance: Tyr^c-2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation comprises a T-to-A transversion at coding nucleotide 1280 of mRNA NM_011661, in the fourth of the gene's five exons (Chr7:87438023 GRCm38). It causes replacement of valine by aspartic acid at amino acid 427 of the tyrosinase protein (p.V427D). (J:159360)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tyr Mutation: 379 strains or lines available

References

• Original: J:159360 Arnold C, et al., Pale rider is an allele of Tyr and causes albinism. MGI Direct Data Submission. 2010
• All: 1 reference(s)