Tg(Gh1-cre)bKnmn
Transgene Detail

Summary

• Symbol: Tg(Gh1-cre)bKnmn
• Name: transgene insertion b, Rhonda D Kineman
• MGI ID: MGI:4442901
• Synonyms: rGHp-Cre
• Transgene: Tg(Gh1-cre)bKnmn Location: unknown
• Alliance: Tg(Gh1-cre)bKnmn page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Gh1-cre)bKnmn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Gh1 (24391)

  Gh	(MGI:95707)

• Mutation details: A 310 bp fragment 5' of the initiation codon of the rat growth hormone gene (Gh1) was used to drive cre recombinase in the construct. The purified construct was injected into FVB zygotes. Line b was determined (by Southern blot) to carry 3 copies of the insertion was established and analyzed in detail. RT-PCR results demonstrated high levels of cre mRNA expression in the pituitary, lower levels in the testis, and no expression in any other tissues. (Cre expression was also detected in cephalic extracts from animals at E17.) (J:122251)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gh1 (rat) Summary of all recombinase alleles driven by Gh1. Comparative matrix view of recombinase activities Alliance rat Gh1 gene page

Disease models

Expression

In Mice Carrying this Mutation:

6 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:122251 Luque RM, et al., Reporter expression, induced by a growth hormone promoter-driven Cre recombinase (rGHp-Cre) transgene, questions the developmental relationship between somatotropes and lactotropes in the adult mouse pituitary gland. Endocrinology. 2007 May;148(5):1946-53
• All: 22 reference(s)