Syk^{tm1.1(cre)Fkfr}
Targeted Allele Detail

Summary

• Symbol: Syk^{tm1.1(cre)Fkfr}
• Name: spleen tyrosine kinase; targeted mutation 1.1, Friedemann Kiefer
• MGI ID: MGI:4442917
• Synonyms: Syk-Cre^delta
• Gene: Syk Location: Chr13:52737209-52802828 bp, + strand Genetic Position: Chr13, 27.41 cM, cytoband B-C2
• Alliance: Syk^{tm1.1(cre)Fkfr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159112
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Syk^{tm1.1(cre)Fkfr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Syk (MGI:99515)

• Mutation details: The pgk-neo cassette was excised from the Sykb^tm1(cre)Fkfr allele by crossing the animals to Pgk-FLPe deleter mice, generating the Sykb^{tm1.1(cre)Fkfr} (delta) allele. (J:159112)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Syk (mouse) Summary of all recombinase alleles driven by Syk. Alliance mouse Syk gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syk Mutation: 42 strains or lines available

References

• Original: J:159112 Bohmer R, et al., Regulation of developmental lymphangiogenesis by Syk(+) leukocytes. Dev Cell. 2010 Mar 16;18(3):437-49
• All: 1 reference(s)