Arl6^tm1Vcs
Targeted Allele Detail

Summary

• Symbol: Arl6^tm1Vcs
• Name: ADP-ribosylation factor-like 6; targeted mutation 1, Val C Sheffield
• MGI ID: MGI:4442928
• Synonyms: Bbs3L^-
• Gene: Arl6 Location: Chr16:59433312-59459754 bp, - strand Genetic Position: Chr16, 34.83 cM, cytoband C1.2
• Alliance: Arl6^tm1Vcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159222
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The splice acceptor and splice donor sites of exon 8 were mutated (AG->AC and GT->CT, respectively) and a neo cassette was inserted downstream of the modified exon 8. The nucleotide substitutions are predicted to result in the exclusion of exon 8 of the long transcript. RT-PCR confirmed the expression of the modified allele. (J:159222)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Arl6 Mutation: 24 strains or lines available

References

• Original: J:159222 Pretorius PR, et al., Identification and functional analysis of the vision-specific BBS3 (ARL6) long isoform. PLoS Genet. 2010;6(3):e1000884
• All: 1 reference(s)