Mapttm2.1(RHOA*)Klt
Targeted Allele Detail
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Symbol: |
Mapttm2.1(RHOA*)Klt |
Name: |
microtubule-associated protein tau; targeted mutation 2.1, Kerry Lee Tucker |
MGI ID: |
MGI:4442945 |
Synonyms: |
N19-RhoA |
Gene: |
Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
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Alliance: |
Mapttm2.1(RHOA*)Klt page
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Germline Transmission: |
Earliest citation of germline transmission:
J:159220
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Dominant negative, Humanized sequence, Inserted expressed sequence) |
Mutations: |
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Insertion, Intragenic deletion
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Mapttm2.1(RHOA*)Klt expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
RHOA (387) |
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Mutation details: Cre mediated recombination removed the floxed STOP cassette allowing for the expression of the dominant-negative transcript.
(J:159220)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mapt Mutation: |
429 strains or lines available
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Original: |
J:159220 Sanno H, et al., Control of postnatal apoptosis in the neocortex by RhoA-subfamily GTPases determines neuronal density. J Neurosci. 2010 Mar 24;30(12):4221-31 |
All: |
1 reference(s) |
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