Dact1^tm1.2Bnrc
Targeted Allele Detail

Summary

• Symbol: Dact1^tm1.2Bnrc
• Name: dishevelled-binding antagonist of beta-catenin 1; targeted mutation 1.2, Benjamin N R Cheyette
• MGI ID: MGI:4442991
• Synonyms: Dact1^flox
• Gene: Dact1 Location: Chr12:71356658-71366881 bp, + strand Genetic Position: Chr12, 29.39 cM
• Alliance: Dact1^tm1.2Bnrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159217
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a frt-flanked neomycin resistance (neo) cassette, followed by a loxP site, upstream of exon 2, and a second loxP site downstream of exon 2. Flp-mediated recombination removed the neo cassette leaving exon 2 floxed. (J:152701, J:159217)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dact1 Mutation: 21 strains or lines available

References

• Original: J:159217 Okerlund ND, et al., Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain. J Neurosci. 2010 Mar 24;30(12):4362-8
• All: 3 reference(s)