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Dok3tm1Ppp
Targeted Allele Detail
Summary
Symbol: Dok3tm1Ppp
Name: docking protein 3; targeted mutation 1, Pier Paolo Pandolfi
MGI ID: MGI:4443003
Gene: Dok3  Location: Chr13:55671044-55677109 bp, - strand  Genetic Position: Chr13, 30.06 cM
Alliance: Dok3tm1Ppp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158011
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExons 3-5 were disrupted by insertion of a cassette containing GFP (in frame) and neo (in reverse orientation). No GFP expression was detected in lung or peripheral blood. The absence of protein expression was confirmed by western blot analysis on splenocyte extracts. (J:158011)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Phenotypes:
Affected Systems
show or hide all annotated terms
     
growth/size/body
pulmonary hyperplasia
hematopoietic system
increased leukocyte cell number
immune system
increased leukocyte cell number
mortality/aging
premature death
neoplasm
increased chronic myelocytic leukemia incidence
increased lung tumor incidence
increased lung adenocarcinoma incidence
respiratory system
pulmonary hyperplasia
increased lung tumor incidence
increased lung adenocarcinoma incidence
increased bronchioalveolar stem cell number
abnormal pulmonary alveolus morphology
increased type II pneumocyte number
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Dok3tm1Ppp
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dok3 Mutation:  18 strains or lines available
References
Original:  J:158011 Berger AH, et al., Identification of DOK genes as lung tumor suppressors. Nat Genet. 2010 Mar;42(3):216-23
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory