Gt(ROSA)26Sor^{tm1.1(CAG-Trp53*,-EGFP)Medz}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(CAG-Trp53*,-EGFP)Medz}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Ruslan Medzhltov
• MGI ID: MGI:4443071
• Synonyms: R26-mp53delta
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(CAG-Trp53*,-EGFP)Medz} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158953
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(CAG-Trp53*,-EGFP)Medz} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Trp53 (MGI:98834)

• Mutation details: Cre mediated recombination removed the floxed neo cassette allowing ubiquitous and moderate expression of the mutated cDNA and EGFP. (J:158953)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:158953 Bondar T, et al., p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell. 2010 Apr 2;6(4):309-22
• All: 1 reference(s)