Slc2a8^tm1.1Asch
Targeted Allele Detail

Summary

• Symbol: Slc2a8^tm1.1Asch
• Name: solute carrier family 2, (facilitated glucose transporter), member 8; targeted mutation 1.1, Annette Schuermann
• MGI ID: MGI:4450978
• Synonyms: GLUT8 knockout, Slc2a8^-
• Gene: Slc2a8 Location: Chr2:32863002-32872095 bp, - strand Genetic Position: Chr2, 22.09 cM
• Alliance: Slc2a8^tm1.1Asch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159441
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 5 and another downstream of exon 7; a PGK-neo/HSV-tk cassette (neo/tk) followed by a third loxP site was inserted in intron 7 further downstream. The present allele was generated by Cre recombinase excision of the neo/tk cassette and exons 5 through 7 of the endogenous gene. (J:159441)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc2a8 Mutation: 19 strains or lines available

References

• Original: J:159441 Gawlik V, et al., Targeted disruption of Slc2a8 (GLUT8) reduces motility and mitochondrial potential of spermatozoa. Mol Membr Biol. 2008 Apr;25(3):224-35
• All: 3 reference(s)