Stim2^tm1Beni
Targeted Allele Detail

Summary

• Symbol: Stim2^tm1Beni
• Name: stromal interaction molecule 2; targeted mutation 1, Bernhard Nieswandt
• MGI ID: MGI:4452038
• Gene: Stim2 Location: Chr5:54155865-54278399 bp, + strand Genetic Position: Chr5, 29.69 cM
• Alliance: Stim2^tm1Beni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159604
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The genomic sequence spanning most of exon 4 through exon 7 was replaced with lacZ and a neo cassette. The absence of protein expression was confirmed by western blot analysis on brain and lymph node cell extracts. (J:159604)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stim2 Mutation: 42 strains or lines available

References

• Original: J:159604 Berna-Erro A, et al., STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death. Sci Signal. 2009;2(93):ra67
• All: 5 reference(s)